个人简介：

刘红荣，湖南科技大学物理学本科，湘潭大学凝聚态物理博士，美国加州大学洛杉矶分校博士后，国家重大人才工程特聘教授，国家“万人计划”科技创新领军人才，全国高校黄大年式教师团队（304am永利集团官网物理学科教师团队）负责人。现任304am永利集团官网教授、博士生导师、副校长。长期从事软物质与生物物理、冷冻电镜方法与应用领域研究，在冷冻电镜病毒近原子分辨三维重构、病毒对称失配及非对称重构领域做出了系列原创性成果，在Science、PNAS、Nat Commun、PLoS Biol等期刊发表论文100余篇。获湖南省自然科学奖一等奖1项（排名第一，2022）、二等奖1项（排名第二，2019），中国侨界贡献二等奖1项（2016），湖南省教学成果奖一等奖1项（排名第一，2025）、二等奖1项（排名第四，2019）。

mail: hrliu@hunnu.edu.cn hrliu2013@126.com

学术贡献：软物质与生物物理；冷冻电镜方法与应用

教学情况：X射线与电子显微学；光学；计算物理；凝聚态物理前沿

承担的主要科研项目：

1. 国家自然科学基金面上项目：基于冷冻电镜技术的巨型噬菌体全病毒结构及感染机制研究（32671601）

2. 国家自然科学基金重点项目：冷冻电镜病毒非对称重构研究（12034006）

3. 国家自然科学基金面上项目：冷冻电镜噬菌体对称失配重构研究（32071209）

4. 湖南省自然科学基金创新研究群体项目：显微成像理论及生物应用（2019JJ1002）

5. 国家重点研发计划课题：冷冻电镜原子分辨结构解析高效算法的开发与应用（2016YFA0501103）

6. 国家自然科学基金重大研究计划（高性能科学计算的基础算法与可计算建模）集成项目：冷冻电镜三维重构的关键算法研究及其应用（91530321）

7. 国家自然科学基金面上项目：基于冷冻电镜二十面体对称失配三维重构的腺病毒结构研究（31570742）

8. 国家自然科学基金面上项目：双链RNA病毒甲基转移酶活性位点的空间定位—冷冻电镜原子分辨三维重构（31370736）

9. 国家自然科学基金重大研究计划项目（高性能科学计算的基础算法与可计算建模）培育项目：基于球坐标系的冷冻电镜二十面体病毒高分辨三维重构的算法研究（91230116）

10. 国家自然科学基金面上项目：最大熵方法在冷冻电镜单颗粒技术中的应用（31170706）

11. 国家自然科学基金面上项目：冷冻电镜单颗粒技术中测定生物大分子颗粒取向的新算法研究（31070663）

主要论文列表：

1. Yuan Chen#,Yuning Peng#, Yuanyuan Liu, Yewei Zhang, Hao Xiao, Wenyuan Chen, Binning Sun, Jianxun He, Xiaorong Yang,Jing Zheng*, and Hongrong Liu*, Intact architectures of myophage phi92 in extended and contracted states, PLoS Pathogens 2026, 22(8): e1014494.

2. Hao Xiao#, Zeng Peng#, Junquan Zhou#, Yuan Chen, Yuning Peng, Yixiong Tang, Tao Li, Wenyuan Chen, Sheng-You Huang, Lingpeng Cheng, Hongrong Liu*, Structural atlas of the intact jumbo phage phiKZ, Nat Commun 2026, 17: 5148.

3. Chen Li#, Jiayi Liu#, Xinran Long, Linger Qian, Jiajie Xie, Chaoqun Luo, Xiaorong Yang, Yanming He, Yushan Zhang, Hui Cai, Jiayi Wang, Fan Yang, Ming Jang, Hongrong Liu*, Shengbiao Hu*. Isolation and characterization of Avs-1, a bacteriophage effectiveagainst the aquaculture pathogen Aeromonas veronii. Appl Environ Microbiol 2026, 10.1128/aem.02334-25.

4. Yuning Peng, Hao Pang, Jing Zheng, Junquan Zhou, Wenyuan Chen, Fan Yang*, Hao Xiao*, and Hongrong Liu*, Structure of a Brochothrix thermosphacta bacteriophage reveals the cell wall adsorption mechanism in Gram-positive infecting siphophages, Nat Commun 2026, 17: 1772.

5. Jing Zheng#, Yuan Chen#, Siting Chen, Junquan Zhou, Hao Xiao, Fan Yang*, and Hongrong Liu*, Structure of defense against restriction proteins DarA and Hdf in phage P1 reveals a new molecular mechanism during phageassembly, infection and DNA ejection, PLoS Pathogens 2026, 22(1): e1013869.

6. Linjie Wu, Chen Zhang, Zijian Hu, Xurong Wang*, Hongrong Liu*, Bin Zhu*. SoluBat: A bidirectional mamba framework for high-throughput protein solubility prediction in bioprocess optimization. Process Biochemistry 2026, 161: 139-151.

7. Wenyuan Chen#, Jing Zheng#, Junquan Zhou, Lingpeng Cheng, and Hongrong Liu*, A data-processing strategy of asymmetric reconstruction for tailed phages by Cryo-electron Microscopy, J Struct Biol 2025, 217: 108262.

8. Binning Sun#, Jing Zheng#, Yuan Fu, Fengyuan Tian, Hao Xiao, Su Li13, Lingpeng Cheng, Ping Chen*, and Hongrong Liu*, Cryo-EM structure of drug-resistant Escherichia coli phage E1004 reveals a conserved cylindrical core among podophages, Structure 2025,34 (2): 229-239.

9. Hao Xiao, Hao Pang, Junquan Zhou, Hao Feng, Jingdong Song, Lingpeng Cheng, Li Wang*, Hongrong Liu*. Structural insights into minor and core proteins of bovine adenovirus 3: bridging capsid and genomic core. J Mol Biol 2025, 437: 169208.

10. Jing Zheng#, Hao Pang#, Hao Xiao, Junquan Zhou, Zhonghua Liu, Wenyuan Chen*, and Hongrong Liu*. Asymmetric structure of podophage N4 represented in Schitoviridae family reveals a type of tube-sheath short-tail architecture. Structure 2025, 33: 1250–1262.

11. Hao Xiao#, Wenyuan Chen#, Hao Pang, Jing Zheng, Li Wang, Hao Feng, Jingdong Song,*, Lingpeng Cheng*, Hongrong Liu*. Structure of the scaffolding protein and portal within the bacteriophage P22 procapsid provides insights into the self-assembly process. PLoS Biology 2025, 23(4): e3003104.

12. Yuan Chen, Hao Xiao, Junquan Zhou, Zeng Peng, Yuning Peng, Jingdong Song, Jing Zheng*, Hongrong Liu*. The in situ structure of T-series T1 reveals a conserved Lambda-like tail tip. Viruses 2025, 17: 351.

13. Junquan Zhou#, Liwen Wang#, Hao Xiao, Wenyuan Chen, Zhonghua Liu, Jingdong Song, Jing Zheng*, Hongrong Liu*, In–situ structures of the contractile nanomachine Myophage Mu in both its extended and contracted states, J Virol 2025, 99(3): doi.org/10.1128/jvi.02056-24

14. 刘媛媛#,周俊权#,张烨伟,郑静*,刘红荣*，噬菌体phi92非对称结构揭示了一种新颖的多套尾 纤维的纳米机器,电子显微学报2025, 44 (1): 73-86.

15. Jing Zheng#, Hao Xiao#, Hao Pang, Li Wang, Jingdong Song, Wenyuan Chen*, Lingpeng Cheng*, and Hongrong Liu*, Conformational changes in and translocation of small proteins: Insights into the ejection mechanism of podophages,J Virol 2025, 99 (1): e01249-24.

16. Hao Pang#, Fenxia Fan#, Jing Zheng#, Hao Xiao, Zhixue Tan, Jingdong Song*, Biao Kan*, Hongrong Liu*, Three-dimensional structures of Vibrio cholerae typing podophage VP1 in two states,Structure 2024, 32: 2364-2374.

17. Yuning Peng#, Huanrong Tang#, Hao Xiao, Wenyuan Chen, Jingdong Song, Jing Zheng*, and Hongrong Liu*, Structures of Mature and Urea-Treated Empty Bacteriophage T5: Insights into Siphophage Infection and DNA Ejection, Int J Mol Sci 2024, 25: 8479.

18. Lei Cao#, Nan Wang#, Zhe Lv#, Wenyuan Chen#, ZHonghao Chen, Lifei Song, Xueyan Sha, Guiqiang Wang, Yaling Hu, Xiaojun Lian, Guoliang Cui, Jinyan Fan, Yaru Quan, Hongrong Liu*, Hai Hou*, Xiangxi Wang*, Insights into variceIIa-zoster virus assembly from the B- and C-capsid at near-atomic resolution structures, hLife 2024, 2: 65-74.

19. Hao Xiao#, Le Tan#, Zhixue Tan#, Yewei Zhang, Wenyuan Chen, Xiaowu Li, Jingdong Song*, Lingpeng Cheng*, and Hongrong Liu*,Structure of the siphophage neck-tail complex suggests that conserved tail tip proteins facilitate receptor binding and tail assembly, PLoS Biol 2023, 21(12): e3002441.

20. Jing Zheng#, Wenyuan Chen#, Hao Xiao, Fan Yang, Jingdong Song, Lingpeng Cheng*, and Hongrong Liu*, Asymmetric Structure of Podophage GP4 Reveals a Novel Architecture of Three Types of Tail Fibers, J Mol Biol 2023,435: 168258.

21. Fan Yang#, Liwen Wang#, Junquan Zhou#, Hao Xiao and Hongrong Liu*. In Situ Structures of the Ultra-Long Extended and Contracted Tail of Myoviridae Phage P1,Viruses 2023, 15: 1267.

22. Hao Xiao, Junquan Zhou, Fan Yang, Zheng Liu, Jingdong Song, Wenyuan Chen*, Hongrong Liu*, and Lingpeng Cheng*. Assembly and Capsid Expansion Mechanism of Bacteriophage P22 Revealed by High-Resolution Cryo-EM Structures, Viruses 2023, 15: 355.

23. Jing Zheng#, Wenyuan Chen#, Hao Xiao, Fan Yang, Xiaowu Li, Jingdong Song, Lingpeng Cheng*, and Hongrong Liu*, A Capsid Structure of Ralstonia solanacearum podoviridae GP4 with a Triangulation Number T = 9, Viruses 2022, 14, 2431.

24. Zhen Han#, Wanjuan Yuan#, Hao Xiao, Li Wang, Junxia Zhang, Yuning Peng, Lingpeng Cheng*, Hongrong Liu*, and Li Huang*, Structural insights into a spindle-shaped archaeal virus with a seven-fold symmetrical tail, Proc Natl Acad Sci USA 2022, 119: e2119439119.

25. Zhe Chen#, Linlin Bao#, Bin Zhu#, Hua Fu#, Shuangli Zhu, Tianjiao Ji, Ying Xue, Chuan Liu, Xurong Wang, Fengdi Li, Qi Lv, Feifei Qi, Pin Yu, Wei Deng, Wenbo Xu*, Chuan Qin*, Hongrong Liu* and Qi Jin*. Structural and functional analysis of a potent human neutralizing antibody against enterovirus A71, Science China Life Sciences 2022, 65(12): 2517-2526.

26. Wenyuan Chen#, Hao Xiao#, Li Wang#, Xurong Wang, Zhixue Tan, Zhen Han, Xiaowu Li, Fan Yang, Zhonghua Liu, Jingdong Song*, Hongrong Liu*, and Lingpeng Cheng*, Structural changes in bacteriophage T7 upon receptor-inducedgenome ejection, Proc Natl Acad Sci USA 2021, 118: e2102003118.

27. Wenyuan Chen#, Hao Xiao#, Xurong Wang, Shuanglin Song, Zhen Han, Xiaowu Li, Fan Yang,Li Wang, Jingdong Song*, Hongrong Liu*, Lingpeng Cheng*. Structural changes of a bacteriophage upon DNA packaging and maturation,Protein Cell 2020, 11(5):374–379.

28. Nan Wang#, Wenyuan Chen#, Ling Zhu#, Dongjie Zhu, Rui Feng, Jialing Wang, Bin Zhu, Xinzheng Zhang, Xiaoqing Chen, Xianjie Liu, Runbin Yan, Dongyao Ni, Grace Guoying Zhou, Hongrong Liu*, Zihe Rao*, Xiangxi Wang*. Structures of the portal vertex reveal essential protein-protein interactions for Herpesvirus assembly and maturation, Protein Cell 2020, 11(5): 366–373.

29. Xiaowu Li,Li Wang,Xurong Wang,Wenyuan Chen, Tao Yang,Jingdong Song*,Hongrong Liu*,LingpengCheng*, Structure of RdRps Within a Transcribing dsRNA Virus Provides Insights Into the Mechanisms of RNA Synthesis, J Mol Biol 2020, 432: 358-366.

30. Xurong Wang, Fuxian Zhang, Rui Su, Xiaowu Li, Wenyuan Chen, Qingxiu Chen, Tao Yang, Jiawei Wang, Hongrong Liu*, Qin Fang*, Lingpeng Cheng*. Structure of RNA polymerase complex and genome within a dsRNA virus provides insights into the mechanisms of transcription and assembly.Proc Natl Acad Sci USA 2018, 115: 7344-7349.

31. Ling Zhu, Yao Sun, Jinyan Fan, Bin Zhu, Lei Cao, Qiang Gao, Yanjun Zhang, Hongrong Liu, Zihe Rao*, and Xiangxi Wang*. Structures of Coxsackievirus A10 unveil the molecular mechanisms of receptor binding and viral uncoating. Nat Commun 2018, 9:4985.

32. Jialing Wang, Shuai Yuan, Dongjie Zhu, Hao Tang, Nan Wang, Wenyuan Chen, Qiang Gao, Yuhua Li, Junzhi Wang, Hongrong Liu*, Xinzheng Zhang*, Zihe Rao*, and Xiangxi Wang*. Structure of the herpes simplex virus type 2 Ccapsid with capsid-vertex-specific component. Nat Commun 2018, 9: 3668.

33. Bin Zhu, Lingpeng Cheng*, Hongrong Liu*, Computing methods for icosahedral and symmetry-mismatch reconstruction of viruses by cryo-electron microscopy, Chin Phys B 2018, 27(5): 056802

34. Shuai Yuan, Jialing Wang, Dongjie Zhu, Nan Wang, Qiang Gao, Wenyuan Chen, Hao Tang, Junzhi Wang*, Xinzheng Zhang*, Hongrong Liu*, Zihe Rao*, and Xiangxi Wang*, Cryo-EM structure of a Herpesvirus capsid at 3.1 Å, Science 2018, 360: eaao7283.

35. Xiaowu Li, Niyun Zhou, Wenyuan Chen, Bin Zhu, Xurong Wang, Bin Xu, Jiawei Wang, Hongrong Liu*, and Lingpeng Cheng*. Near-atomic resolution structure determination of a cypovirus capsid and polymerase complex using cryo-EM at 200 kV, J Mol Biol 2017, 429: 79-87.

36. Xiaowu Li, Hongrong Liu*, Lingpeng Cheng*, Symmetry-mismatch reconstruction of genomes and associated proteins within icosahedral viruses using cryo-EM,Biophys Rep 2016, 2: 25-32.

37. Hongrong Liu*，Lingpeng Cheng*，Cryo-EM shows the polymerase structures and a nonspooled genome within a dsRNA virus,Science 2015, 349: 1347-1350.

38. Bin Zhu, Chongwen Yang, Hongrong Liu*, Lingpeng Cheng*, Feng Song, Songjun Zeng, Xiaojun Huang, Gang Ji, Ping Zhu,Identification of the Active Sites in the Methyltransferases of a Transcribing dsRNA Virus, J Mol Biol 2014, 426: 2167-2174.

39. Changchun Cao, Xiaoyan Dong, Xiaobing Wu, Boyun Wen, Gang Ji, Lingpeng Cheng*, and Hongrong Liu*, Conserved fiber-penton base interaction revealed by a near-atomic resolution cryo-EM structure of adenovirus provides insight into receptor interaction, J Virol 2012, 86: 12322-12329.

40. Hongrong Liu, Lily Wu, Z Hong Zhou*. Model of the trimeric fiber of human adenovirus 5 and its interactions with the pentameric penton base by cryo-electron microscopy, J Mol Biol 2011,406: 764-774.

41. Hongrong Liu，Lei Jin，Sok Boon S. Koh，Ivo Atanasov，Stan Schein，Lily Wu，Z Hong Zhou*. Atomic structure of human adenovirus by cryoEM reveals interactions among protein networks,Science 2010,329: 1038-1043.

42. Hongrong Liu, Lingpeng Cheng, Songjun Zeng, Canying Cai Z. Hong Zhou, Qibin Yang*, Symmetry-adapted spherical harmonics method for high-resolution 3D single particle reconstructions, J Strul Boil 2008,161:64-73.

主要获奖情况：

1. 湖南省高等教育（本科）教学成果奖一等奖：厚重基础 科教融汇：物理学卓越教师与拔尖创新人才“双核共生”培养实践（2025）

2. 湖南省自然科学奖一等奖：冷冻电镜三维重构算法研究与病毒原子结构解析（2022）

3. 湖南省先进工作者（2020）

4. 304am永利集团官网利君育人先锋奖（2018）

5. 第七届中国侨界贡献奖二等奖（2018）